NO2 Information

NO2 has created a revolutionary new category of muscle-builders and muscle-enhancers known as “cell-signaling hemodilators”.

Through mediation of the “signaling-molecule” nitric oxide (NO), NO2 induces powerful hemodilation and creates dramatic increases in muscle size, strength, endurance, power output, and load capacity.

With its advanced sustained-release technology pHyser3, NO2 generates a virtual permanent muscle pump, now known as the “perpetual pump.”

NO2 was created by the same man who introduced Creatine to the market in 1993 - Ed Byrd, co-founder of EAS(tm) and now president of MRI(tm) (Medical Research Institute).

How NO2 Works

NO2 creates - and sustains - levels of nitric oxide in the skeletal muscles.

Nitric oxide is the muscle's “cell-signaling” molecule responsible for blood flow (hemodilation), oxygen delivery, glucose uptake, muscle velocity, power output, and muscle growth.

By creating and then sustaining levels of nitric oxide in the skeletal muscles NO2 delivers continuous muscle-enhancing benefits around the clock. Like amplifying muscle-growth signals for faster gains in lean mass, accelerating both fast and slow twitch muscle fiber for greater strength, providing complete “full-body muscle recovery”, and increasing endurance index (EI).

In addition, NO2's sustained hemodilation (continuous and amplified blood-surge to the skeletal muscles) generates a “perpetual pump”.

Before the introduction of NO2, hemodilation occurred only during intense exercise, and lasted for a relatively brief time. Now, with NO2's extended-release delivery system pHyser3, it is possible for hemodilation to last all day long! That means greater results and faster gains for you. And, of course, a “perpetual pump.”

The NO2 Difference

The NO2 difference is this:

• No other supplement can sustain levels of nitric oxide AND generate a continual and amplified blood-surge (hemodilation) in skeletal muscles.

Until the creation of NO2's extended-release delivery system (pHyser3), generating and maintaining nitric oxide levels was impossible. The human body's pH factor literally dissolved any agent or substance that could help generate nitric oxide inside the body. Now, with NO2's pH-corrected, body-compatible delivery system, pHyser3, the human body is able to not only accept the nitric oxide delivery agent, but also sustain levels of nitric oxide in the muscles throughout the entire day.

Now athletes and bodybuilders can finally get all the powerful benefits of hemodilation - all day long! Including faster gains in muscle mass, increased strength and endurance, and the creation of the “perpetual pump”.

Hemodilation™

Hemodilation means a widening of the blood channels leading to skeletal muscles through the mechanism of amplified blood flow.

The word “Hemodilation” comes from combining 'Hemo' [from the Greek word 'haima' meaning blood] and 'Dilator' [from the Latin word 'dilatare' meaning to widen]. The measure of the widening of the blood canals is calculated by the “dilation differential(tm)” - known as d-delta™.

Hemodilation is initiated by nitric oxide synthesis. Nitric oxide is the cell-signaling molecule responsible for blood flow, oxygen delivery, glucose uptake, muscle velocity, power output, and gene-expression, or muscle growth. By sustaining nitric oxide levels in the skeletal muscles, NO2 generates its sustained hemodilation. The channels that deliver muscle building agents to the muscle cells become forced open and remain that way throughout the day. The results are faster gains in lean mass, greater strength, increased endurance, complete full-body muscle recovery, and a “perpetual pump.”

NOTE: Hemodilation is a new term that came into existence with the discovery of nitric oxide (NO). Under ordinary circumstances, hemodilation lasts only briefly. With the introduction of NO2, however, and the sustained NO levels it generates in the skeletal muscle, sustained hemodilation became a reality. The word hemodilation, as applied to NO2, means sustained hemodilation.

Hemodilation™ vs Cell Volumization

“What I started with Creatine, I perfected with NO2.”   -Ed Byrd

How does NO2's “hemodilation” compare to Creatine's “cell-volumization”?

Because Ed Byrd introduced both Creatine and NO2, he says it best...

“As you probably know, Creatine causes 'cell-volumizing' by pulling water into the small space inside the muscle cell. It does increase size, but you may look a little “puffy”. NO2's hemodilation, on the other hand, creates genuine size by forcing blood into the vast and voluminous spaces between the muscle cells - not inside the cells. This super-engorging creates massive pumps. What's more, because the blood is between the cells not inside them, the pump is rock-hard – not at all puffy.

And with the extended-release delivery system pHyser3, the pump does not go away. You getwhat is known as a “perpetual pump”.

“Frankly, my recommendation to bodybuilders would be to take both Creatine and NO2. I look at it this way, what I started with Creatine, I perfected with NO2.”

What Results Should I See With NO2?

The first result most bodybuilders see (in 5-7 days) is the “perpetual pump.”

The perpetual pump is a massive rock-hard muscle pump that literally does not go away. Unlike the exercise-induced pump that quickly fades with time, the perpetual pump is virtually permanent.

Then, 2-3 days after the appearance of the perpetual pump, you'll start noticing increases in strength and endurance. At the same time, you'll see increases in size in all your skeletal muscles.

Is NO2 Right For Me?

Ask yourself these simple questions:

• Am I happy with my current muscle gains?
• Would I like to get the great-looking pump I get after an intense workout, and keep it all day long?
• Would I like to add more reps and more sets to every workout?

If you answered yes to any of these questions, NO2 is the perfect answer for you.
That's because NO2 gives you:

• Continuous gains in lean mass by triggering forced-growth muscle-signaling action;
• A perpetual pump through its powerful hemodilating effects;
• Greater strength by accelerating your fast-twitch muscle strength;
• complete full-body muscle recovery; and
• Far better workouts by increasing your Endurance Index (EI).

Is NO2 Safe?

Yes. NO2 generates, and maintains, levels of nitric oxide - a substance that is totally natural to your body.

NOTE: There are now 3 categories of substances that help enhance performance: Drugs; Dietary Supplements; and now with the introduction of NO2 - Nutraceutical Expressors.

Drugs, like androgenic anabolic steroids, are foreign to your body. They work powerfully, but because they're a foreign agent, they have many negative side effects. We do not recommend using drugs unless under a doctor's supervision.

Dietary Supplements are naturally occurring substances in your body. They have a moderate range of effectiveness and usually have no side effects.

NO2 - gives you the best of both worlds: powerful results and safety.

Nutraceutical Expressors work by amplifying both volume and action-time of muscle-building agents that are natural to your body. For example:

• Keeping nitric oxide in skeletal muscles for extended periods of time to effectively increase muscle-building protein synthesis
• Inducing sustained hemodilation; and
• Providing complete full-body muscle recovery

 are all examples of the benefits of Nutraceutical Expressors.

When Should I Take NO2?

For maximum results, refer to the chart below. You should start noticing results in about 5-7 days.
IMPORTANT: Remember to drink at least 64 ounces (that's 8 glasses) of water daily while taking NO2.

Don't Leave Your Pump in the Gym!

What is a “perpetual pump”?

A “perpetual pump” is a muscle pump that remains in its post-exercise, blood-engorged, rock-hard condition virtually all the time! The increased muscle size and muscle density achieved through exercise do not fade with time.

How is the “perpetual pump” possible?

The “perpetual pump” is a brand new phenomenon. It's one of the stunning effects of the sustained hemodilation you get from NO2.

“Serious bodybuilders know the skin-ripping, super-pumped look they get immediately after an intense workout” explains Ed Byrd, co-founder of EAS, President of MRI, and the man who introduced bodybuilding's last great breakthrough - Creatine. “Now, thanks to NO2's sustained hemodilating effect, they can keep that super-vascular look all day long.”

Here's how...

Increased blood flow is responsible for your pump. Your body responds to exercise by releasing nitric oxide, the muscle's “signaling molecule” responsible for increased blood flow.

When you exercise hard, Nitric oxide opens the blood floodgates allowing blood to surge in. That's hemodilation, and that's how you get a “pump”. But an exercise-induced pump is only temporary. It disappears soon after the body realizes exercise has ended.

Now, with NO2, pumps do not go away. Even massive, vein-popping pumps show no sign of diminishing. That's because NO2 generates a continuous surge of blood that courses through the skeletal muscle throughout the day. So muscles remain engorged and like steel all day long. The secret of the continuous surge of blood lies in NO2's exclusive extended-release delivery system pHyser3™.

Until an extended-release delivery system was perfected, generating and maintaining nitric oxide levels in the body was impossible. The body literally dissolved any agent or substance that could help generate nitric oxide inside the body. Now, with NO2's pH-corrected, body-compatible delivery system, the human body is able to fully accept the nitric oxide delivery agent.

And even better...NO2 goes far beyond simply generating nitric oxide levels. NO2 maintains nitric oxide levels in the muscles throughout the entire day. So athletes and bodybuilders get all the powerful muscle-developing benefits of hemodilation - all day long! Including the very appealing “perpetual pump.”

NO2

Pinnacle NOX2 is for anyone who wishes to extend their muscle pump, signal muscle growth, speed recovery, increase their strength, stamina and sexual vigor. NO2 can now be found at spectrum-nutrition.com. Get the same product (NOX2) at half the cost from Pinnacle Nutrition. Nitric Oxide, a key molecule manufactured by the body, causes vasodilation (an expansion of the internal diameter of blood vessels), which in turn leads to increased blood flow, oxygen transport, delivery of nutrients to skeletal muscle and a reduction in blood pressure. An amino acid compound called arginine alpha-ketoglutarate (A-AKG) and arginine-ketoisocaproate (A-KIC) can boost short term Nitric Oxide levels. Increased strength and markedly improved stamina can also be expected. In fact, the results may be classified into three categories:

1) the promotion of an extended pump

2) signaling muscle growth and speeding recovery

3) increasing strength and stamina.

Furthermore, Pinnacle utilizes the exclusive A-DS Advanced delivery system in NoX2 which spikes absorption of the active compound to insure uptake and help sustain the powerful vasodilation effects of A-AKG and A-KIC around the clock. Advanced deliver system (A-DS) optimizes (A-AKG) and (A-KIC) in the body. Through a bioactive process, Beta Cyclodextrin, Cephalins, Xanthum and Inulin are combbined with NoX2 to form a unique blended complex, which acts as the "carrier" for the NoX2 "cargo" helping it to be effectively transported throughout the body and delivered directly into the bloodstream. This process also serves as an extended release mechanism, keeping target issues saturated with more consistant levels of desired nutrients and extending benefits (over a 10 hour period) long after other supplements have been spent or wasted.

More about NO2

1. What is it and where does it come from?

Nitric Oxide is a free form gas that is produced in the body and is used by the body to communicate with other cells in the body. To produce this gas, enzymes in the body break down the amino acid Arginine.

Nitric Oxide is a molecule consisting of one atom of nitrogen and one atom of oxygen. The production of Nitric Oxide occurs when the amino acid L-arginine is converted into L-citruline through an enzyme group known as Nitric Oxide Synthase (NOS). The chemical process of conversion is shown in figure 1.

2. What does it do and what scientific studies give evidence to support this?

Despite the claims of some in the supplement industry, there exists ample scientific literature to substantiate the efficacy of Nitric Oxide ( NO2 ) products. The following was written in May 1996 in a document prepared for the Royal Society and Association of British Science Writers:

"Summary research papers continue to flood the scientific journals and insights into the biological activity and potential clinical uses of nitric oxide (NO): a gas controlling a seemingly limitless range of functions in the body. Each revelation adds to nitric oxide's already lengthy resume in controlling the circulation of the blood, regulating activities of the brain, lungs, liver, kidneys, stomach and other organs.

The molecule governs blood pressure through a recently recognized process that contradicts textbook wisdom. It causes penile erection by dilating blood vessels and controls the action of almost every orifice from swallowing to defecation. The immune system uses nitric oxide in fighting viral, bacterial and parasitic infections, and tumors. Nitric oxide transmits messages between nerve cells and is associated with the process of learning, memory, sleeping, feeling pain, and, probably depression. It is a mediator in inflammation and rheumatism."

Since the above was written in 1996, Nitric Oxide containing products have continued to be touted by those in the medical profession, as well as by athletes looking to add muscle to their frames.

The above quotation states that Nitric Oxide controls the circulation of blood, transmits messages between nerve cells, and is a mediator of inflammation and is associated with the process of feeling pain. The popular erectile dysfunction drug sildenafil citrate (Viagra) contains nitric oxide and is responsible for increasing blood flow to the penis.

The fact that nitric oxide increases blood flow should make it of interest to bodybuilders, as increased blood flow will serve to deliver more nutrients to muscles, thus helping muscles become larger when subject to stress. The fact that Nitric Oxide acts to reduce inflammation should also make it of interest to bodybuilders as it has the potential to reduce the pain associated with subjecting muscles to extreme stress.

Nitric oxide also affects the endocrine system. It affects the release of gonadotroptin releasing hormone, as well as the release of adrenaline from the adrenal medulla.

3. Who needs it and what are some symptoms of deficiency?

Everyone REQUIRES nitric oxide to carry out key physiological processes within the body. From a bodybuilder's perspective, nitric oxide supplementation may prove useful in increasing growth due to increases in blood flow to certain areas of the body. Further, men suffering from erectile dysfunction may also find supplementing with nitric oxide helpful.

Signs of deficiency include the inability to achieve and sustain erections, physical weakness and extreme fatigue. Most "nitric oxide" supplements contain the amino acid Arginine-alpha-keto-glutarate.

4. How much should be taken? Are there any side effects?

With any amino acid containing product, overdose is a possibility. Dosing with too much arginine can lead to diarrhea, weakness and nausea. Clear dosing guidelines have not been established, so it is best to do what is known as "tolerance mapping". Take a small dosage for one week, note the benefits and the side effects, and increase the dosage until the benefits are maximized and the side effects minimized. Over time the two will converge and you will hit the optimal dose. This process is similar to "receptor mapping" for bodybuilders who use insulin.

Many protein powders are fortified with amino acids, including arginine. With this in mind, pay particular attention to how much arginine you are ingesting from all supplements taken.